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ChemInform Abstract: Solvent-Free Synthesis of 1-(Hydroxyquinolyl)- and 1-(Hydroxyisoquinolyl)-1,2,3,4-tetrahydroisoquinolines by Modified Mannich Reaction.

✍ Scribed by Istvan Szatmari; Ferenc Fueloep


Publisher
John Wiley and Sons
Year
2011
Weight
32 KB
Volume
42
Category
Article
ISSN
0931-7597

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✦ Synopsis


Abstract

The title reaction is investigated for the compounds (I).


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Synthesis and Properties of Enaminoketohydrazides of 1,2,3,4-Tetrahydroisoquinoline Series. -Reaction of dioxopyrroloisoquinolines (I) with hydrazine proceeds at the lactam carbonyl group with subsequent pyrroledione ring opening to afford the enaminoketohydrazides (II). Compounds (II) are characte