ChemInform Abstract: Solid-Phase Synthesis, Characterization, and Screening of a 43,000- Compound Tetrahydroisoquinoline Combinatorial Library.
β Scribed by M. C. GRIFFITH; C. T. DOOLEY; R. A. HOUGHTEN; J. S. KIELY
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 26 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0931-7597
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Solution-and Solid-Phase Synthesis of Combinatorial Libraries of Trisubstituted 1,3,5-Triazines. -A general synthesis of the title compounds (III) in solution becomes possible by condensation of amidines or thiouronium salts with (I). The approach can be successfully transferred to the solid phase