ChemInform Abstract: Sodium Borohydride-Amberlyst-15(H+): An Effective Reductor for Hindered and Unreactive Ketones in Aprotic Solvent.

✍ Scribed by J. ROBLES CAYCHO; F. GARCIA TELLADO; P. DE ARMAS; J. J. MARRERO TELLADO

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 34 KB
• Volume: 28
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199720055

✦ Synopsis

Sodium Borohydride-Amberlyst-15(H+): An Effective Reductor for Hindered and Unreactive Ketones in Aprotic Solvent.

-The first application of an exchanged-acid resin to the reduction of ketones by sodium borohydride in an aprotic solvent is presented. A variety of organic functions like ketals and silyl ethers is tolerated by this method. The reduction of the most reluctant ketones (Ib) and ( VII) requires 6 g of resin per mmol of ketone and 40 equiv. NaBH4 whereas 1-3 g of resin and 5 equiv. NaBH4 are used in the reductions of more reactive or less hindered ketones. -(ROBLES CAYCHO,