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ChemInform Abstract: Sequential 1,3-Dipolar Cycloadditions in the Synthesis of Bis-isoxazolo Substituted Piperidinones.

✍ Scribed by Kevin Sheng-Lin Huang; Edwin H. Lee; Marilyn M. Olmstead; Mark J. Kurth

Publisher: John Wiley and Sons
Year: 2010
Weight: 31 KB
Volume: 31
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.200018100

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Use of 1,3-Dipolar Cycloaddition for the Synthesis of Novel Fluoroquinolones. -A novel synthetic way for the modification of 6-fluoroquinoline-4-one-3-carboxylic acids is presented. The 7-azido-derivative (II) undergoes 1,3-dipolar cycloaddition to several alkenes like norbornene, cyclopentenonorbo