ChemInform Abstract: Self Reproduction of Chirality in Pyroglutamates: Reactions at α- Position with Electrophiles.
✍ Scribed by D. K. DIKSHIT; A. MAHESHWARI; S. K. PANDAY
- Book ID
- 112023859
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 29 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0931-7597
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Remote O, C-Dianion Chemistry of Pyroglutamates: Reaction at C-4 with Electrophiles. -Lithiation of N-substituted pyroglutamic acids (I) generates O,C-di-lithio enolates which react diastereoselectively with alkyl halides (II) to give exclusively the 4-α-substituted products (IV) after esterificati
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