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ChemInform Abstract: Selective Inhibition of Receptor Tyrosine Kinases by Synthetic Analogues of Aeroplysinin.

✍ Scribed by H. WALDMANN; K. HINTERDING; P. HERRLICH; H. J. RAHMSDORF; A. KNEBEL

Publisher
John Wiley and Sons
Year
2010
Weight
30 KB
Volume
28
Category
Article
ISSN
0931-7597

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## Abstract SU6668 (TSU‐68) is a small‐molecule synthetic inhibitor of the angiogenic related receptor tyrosine kinases Flk‐1/KDR, PDGFRΞ², and FGFR1. Using a mouse model of peritoneally disseminated ovarian cancer, we investigated whether SU6668 inhibits peritoneal dissemination and prolongs surviv