ChemInform Abstract: (S)-2-(Dibenzylamino)-3-phenylpropanal as a Chiral Auxiliary: A New Strategy for the Asymmetric Synthesis of 2-Substituted Alcohols.

✍ Scribed by J. CLAYDEN; C. MCCARTHY; J. G. CUMMING

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 37 KB
• Volume: 29
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199833116

✦ Synopsis

1998 alcohols alcohols (acyclic compounds) P 0110 33 -116 (S)-2-(Dibenzylamino)-3-phenylpropanal as a Chiral Auxiliary: A New Strategy for the Asymmetric Synthesis of 2-Substituted Alcohols.

-The key steps in the synthesis of the title alcohols are nucleophilic addition to the aldehyde (I), which proceeds with 96% diastereoselectivity, and stereospecific rearrangement of allylic alcohols.

-(CLAYDEN, J.;