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ChemInform Abstract: Regioselective Synthesis and Properties of 3-Cyano-6-methyl-4-trifluoromethylpyridine-2(1H)-thione. Molecular and Crystal Structure of 3-Cyano-2-ethylthio-6-methyl-4-trifluoromethylpyridine.

✍ Scribed by K. G. NIKISHIN; V. P. KISLYI; V. N. NESTEROV; A. M. SHESTOPALOV; YU. T. STRUCHKOV; V. V. SEMENOV

Publisher
John Wiley and Sons
Year
2010
Weight
37 KB
Volume
29
Category
Article
ISSN
0931-7597

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✦ Synopsis

Regioselective Synthesis and Properties of 3-Cyano-6-methyl-4-trifluoromethylpyridine-2(1H)-thione.

Molecular and Crystal Structure of 3-Cyano-2-ethylthio-6-methyl-4-trifluoromethylpyridine.

-The base mediated reaction of 1,3-diketone (I) or pentenone (IV) with cyanothioacetamide (II) affords regioselectively the 3-cyano-4-trifluoromethyl-6methylpyridine-2(1H)-thione (III). Thione (III) smoothly undergoes S-alkylation [β†’ (VI), (IX)]. Amides of pyridylthioacetic acid (VI) thus obtained cyclize in alkaline medium furnishing thienopyridinecarboxamides (VII). -(NIK-

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