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ChemInform Abstract: Regioselective Synthesis and in vitro Anticancer Activity of 4-Aza-podophyllotoxin Derivatives Catalyzed by L-Proline.

✍ Scribed by Chunling Shi; Juxian Wang; Hui Chen; Daqing Shi

Publisher
John Wiley and Sons
Year
2010
Weight
31 KB
Volume
41
Category
Article
ISSN
0931-7597

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✦ Synopsis

Abstract

The method shows several advantages such as short reaction times, simple product isolation, recycling of the catalyst, and exclusive regioselectivity of the three‐component reaction in the case of unsymmetrical amines.

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ChemInform Abstract: Green Synthesis of Chromen-2-one Derivatives Catalyzed by L-Proline.
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## Abstract A mild and efficient synthesis of the title compounds (III) via reaction of 4‐hydroxy‐6‐methyl‐pyran‐one with various substituted 2‐hydroxybenzaldehydes in water is described.