ChemInform Abstract: Regio- and Stereoselective Synthesis of Trifluoromethylated Isoxazolidines by 1,3-Dipolar Cycloaddition of 1,1,1-Trifluoro-3- phenylsulfonylpropene with Nitrones, and Their Conversion into Trifluoromethylated syn-3-Amino Alcohols.
β Scribed by H. TSUGE; T. OKANO; S. EGUCHI
- Book ID
- 112028261
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 30 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0931-7597
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## Abstract magnified image Asymmetric 1,3βdipolar cycloadditions of chiral nitrones to 1βpropeneβ1,3βsultone (**1**) were investigated. Chiral nitrones **6aβe** reacted with sultone **1** in toluene at 90 Β°C for 24β36 h to give the corresponding isoxazolidines in moderate yields with high regiose