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ChemInform Abstract: Reaction of the Lithio-Derivative of Methoxy Allene with SAMP-Hydrazones: Access to Enantiopure 3-Pyrrolines.

✍ Scribed by Valerie Breuil-Desvergnes; Philippe Compain; Jean-Michel Vatele; Jacques Gore

Publisher
John Wiley and Sons
Year
2010
Weight
34 KB
Volume
30
Category
Article
ISSN
0931-7597

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✦ Synopsis

Reaction of the Lithio-Derivative of Methoxy Allene with SAMP-Hydrazones: Access to Enantiopure 3-Pyrrolines.

-Depending on the solvent used Ξ±-lithio methoxy allene (I) reacts with SAMP-hydrazones (I) and (V) to give 3-methoxy-3-pyrrolines (III) or Ξ±-allenyl hydrazines (VI). Quaternization of the pyrrolines (IIIa), (IIIb) and following hydrogenolysis affords the chiral pyrrolines (IV) as synthons of biologically interesting molecules. -(BREUIL-DESVERGNES, VALERIE; COMPAIN,

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ChemInform Abstract: Reaction of the Lithio-Derivative of Methoxyallene with Hydrazones. Part 2. Formation of 3-Pyrrolines and Azetidines; Synthetic and Mechanistic Aspects.
✍ Valerie Breuil-Desvergnes; Jacques Gore πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 37 KB πŸ‘ 1 views

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