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ChemInform Abstract: Reaction of 4-Aryl-3-thiosemicarbazides with Carbon Disulfide: A Facile Synthesis of 2,3-Dihydrothiazoles (III) and Their Fused Derivatives.

โœ Scribed by R. M. MOHAREB; S. M. SHERIF


Publisher
John Wiley and Sons
Year
2010
Weight
32 KB
Volume
28
Category
Article
ISSN
0931-7597

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Reaction of 4-aryl-3-thiosemicarbazides
โœ Rafat M. Mohareb; Sherif M. Sherif ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 203 KB ๐Ÿ‘ 2 views

The reaction of 3-aryl-3-thiosemicarbazides 1a-d with carbon disulfide in alkaline medium affords the nonisolable sulfide salts 2a-d. The latter undergo in situ heterocyclization with some โฃ-halogenated compounds, e.g., 3a,b and 13, to afford polyfunctionally substituted 2,3-dihydrothiazoles 4a-e an