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ChemInform Abstract: Reaction of 1-Substituted Tetrahydro-β-carbolines with Activated Alkynes — A New Original Approach to the Synthesis of Tetrahydroazocino[5,4-b]indoles.

✍ Scribed by L. G. Voskressensky; T. N. Borisova; L. N. Kulikova; E. G. Dolgova; A. I. Kleimenov; E. A. Sorokina; A. A. Titov; A. V. Varlamov


Publisher
John Wiley and Sons
Year
2008
Weight
45 KB
Volume
39
Category
Article
ISSN
0931-7597

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Stereochemical Issues Related to the Synthesis of 7,10- 10,16,3':3,4]pyrazino[1,2-b]βcarboline-5,8-diones. -The condensation of iminoethers like (III) with anthranilic acid proceeds with inversion of the tryptophan stereocenter C-16a. Epimerization of the tryptophan center also occurs by acylation