β Scribed by Chang-Sik Kim; K. C. Russell
No coin nor oath required. For personal study only.
Rapid Bergman Cyclization of 1,2-Diethynylheteroarenes.
-The synthesis of quinoxaline (III), pyridine (VI), and pyrimidine enediynes (IX) is achieved by palladium-catalyzed cross-coupling of the corresponding o-dihaloor o-halotriflic hetarenes (I), (V), and (VIII), resp., with trimethylsilylacetylene (II) in the presence of base. All enediynes undergo Bergman cyclization to afford the benzo-anellated analogues (IV), (VII), and (X), respectively. Kinetics of the cyclization is studied and compound (IX) is shown to possess remarkable reactivity. -(KIM, CHANG-SIK;
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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a βFull Textβ option. The original article is trackable v