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ChemInform Abstract: Quinoxaline Chemistry. Part 12. 3-Carboxy-2[phenoxy]-6(7) Substituted Quinoxalines and N-[4-(6(7) Substituted-3-carboxyquinoxalin-2-yl)hydroxy] Benzoylglutamates. Synthesis and Evaluation of in vitro Anticancer Activity.

✍ Scribed by Gabriella Vitale; Paola Corona; Mario Loriga; Giuseppe Paglietti

Publisher: John Wiley and Sons
Year: 2010
Weight: 32 KB
Volume: 30
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199922160

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✦ Synopsis

Quinoxaline Chemistry. Part 12. 3-Carboxy-2[phenoxy]-6(7) Substituted Quinoxalines and N-[4-(6(7) Substituted-3-carboxyquinoxalin-2-yl)hydroxy] Benzoylglutamates. Synthesis and Evaluation of in vitro Anticancer Activity.

-Thirty quinoxalines, bearing a substituted phenoxy or hydroxybenzoylglutamate group in position 2, are prepared in order to evaluate the in vitro anticancer activity. Screening reveals that only few derivatives, e.g. (IIIc) and (IIId), exhibit moderate growth inhibition activity on various tumor panel cell lines.

-(VITALE, GABRIELLA; CORONA,

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