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ChemInform Abstract: Protease-Catalyzed Peptide Synthesis from N- to C-Terminus: An Advantageous Strategy.

✍ Scribed by F. BORDUSA; D. ULLMANN; H.-D. JAKUBKE

Publisher: John Wiley and Sons
Year: 2010
Weight: 25 KB
Volume: 28
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199732173

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✦ Synopsis

Protease-Catalyzed Peptide Synthesis from N-to C-Terminus: An Advantageous Strategy.

-A stepwise enzymatic peptide synthesis in the non-conventional N . fwdarw. C direction avoiding the risks of racemization is demonstrated for the model tetrapeptide H-Lys-Tyr-Arg-Ser-OH using the cysteine protease Clostripain. The tetrapeptide is obtained in 62% overall yield.

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