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ChemInform Abstract: Prodrugs of Neuron-Selective Monoamine Oxidase Inhibitors: Amino Acid Derivatives of 1-(4-Aminophenyl)-2-aminopropanes.

✍ Scribed by Lennart Florvall; Ingrid Fagervall; Lars-Gunnar Larsson; Svante B. Ross

Publisher: John Wiley and Sons
Year: 2010
Weight: 31 KB
Volume: 30
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199929187

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✦ Synopsis

Prodrugs of Neuron-Selective Monoamine Oxidase Inhibitors: Amino Acid Derivatives of 1-(4-Aminophenyl)-2-aminopropanes.

-The most interesting derivative within this series is found to be glycine amide (VII). It is shown that amino acid derivatives show only weak MAO inhibitory activity in vitro but strong, neuron-selective inhibitory activity in vivo. It is also found that enzymatic hydrolysis in intestine by peptidases is necessary for

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