ChemInform Abstract: Process Research and Large-Scale Synthesis of 4′′,6′′-Bis((2-fluorophenyl)carbamoyl)hecogenyl β-O-Cellobioside: A Potent Cholesterol Absorption Inhibitor.

✍ Scribed by F. J. URBAN; R. BREITENBACH; R. A. BUZON; P. J. DANIELS; P. J. DUNN; S. GUT; R. S. LEHNER; S. L. ORRILL; H. A. JUN. WATSON

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 33 KB
• Volume: 29
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199834247

✦ Synopsis

Process Research and Large-Scale Synthesis of 4",6"-Bis((2fluorophenyl)carbamoyl)hecogenyl β-O-Cellobioside:

A Potent Cholesterol Absorption Inhibitor.

-A facile five step synthesis of the title compound (I), which allowed the preparation of 80 kg of high-purity material in good overall yield, is given. -(URBAN, F.