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ChemInform Abstract: Probing the Stereoselectivity of P-Glycoprotein—Synthesis, Biological Activity and Ligand Docking Studies of a Set of Enantiopure Benzopyrano[3,4-b][1,4]oxazines.

✍ Scribed by Ishrat Jabeen; Penpun Wetwitayaklung; Freya Klepsch; Zehida Parveen; Peter Chiba; Gerhard F. Ecker

Publisher: John Wiley and Sons
Year: 2011
Weight: 26 KB
Volume: 42
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.201121164

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✦ Synopsis

Probing the Stereoselectivity of P-Glycoprotein-Synthesis, Biological Activity and Ligand Docking Studies of a Set of Enantiopure Benzopyrano[3,4-b][1,4]oxazines. -Some of the title benzopyranooxazines and their precursors (I)/(II), e.g. (Ib), (Ic), (IIb), (IIc), and (IIIc) demonstrate significant P-glycoprotein inhibitory activity.

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