ChemInform Abstract: Preparation of 2-Cyanobenzoic Acids from the Reaction of Bromobenzoic Acids with Arylacetonitriles and LDA.

✍ Scribed by A. WANG; J. A. MAGUIRE; E. BIEHL

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 36 KB
• Volume: 29
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199834122

✦ Synopsis

Preparation of 2-Cyanobenzoic Acids from the Reaction of Bromobenzoic Acids with Arylacetonitriles and LDA. -Title compounds with specific substitution patterns are readily obtained from reactions of intermediately generated arynes with acetonitriles. The utility of nitrile products is demonstrated by further reactions of acid (VIb) to yield anhydride ((VIII) and isoindole (X). -(WANG, A.;