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ChemInform Abstract: Practical Synthesis of the Calcimimetic Agent, Cinacalcet.

✍ Scribed by Oliver R. Thiel; Charles Bernard; Wanda Tormos; Alan Brewin; Shuji Hirotani; Kazuo Murakami; Kenji Saito; Robert D. Larsen; Michael J. Martinelli; Paul J. Reider

Publisher
John Wiley and Sons
Year
2008
Weight
16 KB
Volume
39
Category
Article
ISSN
0931-7597

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A dimethylzinc/diphenylphosphinoylimine
A dimethylzinc/diphenylphosphinoylimine approach to the asymmetric synthesis of the calcimimetic agent NPS R-568
✍ Sucharita Banerjee; Brad Smith; Shawn R. Hitchcock πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons 🌐 English βš– 127 KB

## Abstract An asymmetric synthesis of the calcimimetic agent NPS R‐568 using a (1__R__,2__S__)‐__N__‐benzylephedrine‐promoted addition of dimethylzinc to a diphenylphosphinoylimine derived from 3‐methoxybenzaldehyde is described. The enantiomeric ratio of the key amine fragment was determined to b