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ChemInform Abstract: Practical Synthesis of 9-(2,3-Dideoxy-2-fluoro-β-D-threo-pentofuranosyl)adenine (FddA) via a Purine 3′-Deoxynucleoside.

✍ Scribed by Satoshi Takamatsu; Tokumi Maruyama; Satoshi Katayama; Naoko Hirose; Masaki Naito; Kunisuke Izawa

Publisher: John Wiley and Sons
Year: 2010
Weight: 33 KB
Volume: 32
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.200127205

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## Abstract A quick and sensitive reversed‐phase HPLC method has been developed for the analysis of 2′‐β ‐fluoro‐2′,3′‐dideoxy adenosine (F‐ddA), the acid‐stable anti‐AIDS drug, and its metabolite 2′‐fluoro‐2′,3′‐dideoxy inosine (F‐ddI) in human plasma using polyfluorinated stationary phase column