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ChemInform Abstract: Practical Synthesis of 4-Fluoroprolines.

โœ Scribed by Mukund S. Chorghade; Debendra K. Mohapatra; Gokarneswar Sahoo; Mukund K. Gurjar; Manish V. Mandlecha; Nitin Bhoite; Santosh Moghe; Ronald T. Raines


Publisher
John Wiley and Sons
Year
2009
Weight
33 KB
Volume
40
Category
Article
ISSN
0931-7597

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ChemInform Abstract: A Practical Synthes
โœ Erick R. R. Young; Raymond L. Funk ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 27 KB ๐Ÿ‘ 1 views

The practical multigram synthesis of the title compound (IV) involves a crucial intramolecular acyloin condensation of the diester with excess sodium in refluxing THF. The dione (IV) is obtained in high yield after aerobic work-up. -(YOUNG, ERICK