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ChemInform Abstract: Potential Antiviral Agents. Part 2. Synthesis and Antiviral Evaluation of Pyrazinones Substituted with Acyclic Chains.

✍ Scribed by J. DAVIS; R. BENHADDOU; O. FEDORYAK; R. GRANET; P. KRAUSZ; C. BLIARD; M. DE MONTE; A. M. AUBERTIN


Publisher
John Wiley and Sons
Year
2010
Weight
35 KB
Volume
29
Category
Article
ISSN
0931-7597

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✦ Synopsis


Potential Antiviral Agents. Part 2. Synthesis and Antiviral Evaluation of Pyrazinones Substituted with Acyclic Chains.

-A series of 4'-substituted hydroxybutyl pyrazine analogues of the anti-herpes compound acyclovir is prepared by azidation and glycosylation. The antiviral (HSV-1, CMV, Cox B4, HIV-1) potential of these analogues is evaluated. However, none of the analogues shows antiviral activity. -(DAVIS,


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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a β€œFull Text” option. The original article is trackable v