ChemInform Abstract: Potent Memapsin 2 (β-Secretase) Inhibitors: Design, Synthesis, Protein-Ligand X-Ray Structure, and in vivo Evaluation.

ChemInform Abstract: Protein Structure-B

ChemInform Abstract: Protein Structure-Based Design, Synthesis, and Biological Evaluation of 5-Thia-2,6-diamino-4(3H)-oxopyrimidines: Potent Inhibitors of Glycinamide Ribonucleotide Transformylase with Potent Cell Growth Inhibition.

✍ M. D. VARNEY; C. L. PALMER; W. H. III ROMINES; T. BORITZKI; S. A. MARGOSIAK; R. 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 32 KB 👁 1 views

Protein Structure-Based Design, Synthesis, and Biological Evaluation of 5-Thia-2,6-diamino-4(3H)-oxopyrimidines: Potent Inhibitors of Glycinamide Ribonucleotide Transformylase with Potent Cell Growth Inhibition. -A novel series of inhibitors such as (I) and (II) are prepared and designed using the X