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ChemInform Abstract: Potent and Selective 5-LO Inhibitor Bearing Benzothiophene Pharmacophore: Discovery of MK-5286.

✍ Scribed by Lianhai Li; Carl Berthelette; Anne Chateauneuf; Marc Ouellet; Claudio F. Sturino; Zhaoyin Wang

Publisher
John Wiley and Sons
Year
2011
Weight
21 KB
Volume
42
Category
Article
ISSN
0931-7597

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✦ Synopsis

Abstract

The synthesized substituted title benzothiophene (I) is able to serve as a novel scaffold of 5‐lipoxygenase (5‐LO) inhibitors and is selected to advance into pre‐clinical development.

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