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ChemInform Abstract: Polyaniline-Supported Cobalt(II) Salen Catalyzed Synthesis of Pyrrolidine Containing α-Hydroxyamide Core Structures as Inhibitors for HIV Proteases.

✍ Scribed by T. PUNNIYAMURTHY; J. IQBAL

Publisher: John Wiley and Sons
Year: 2010
Weight: 34 KB
Volume: 28
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199739219

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✦ Synopsis

Polyaniline-Supported Cobalt(II) Salen Catalyzed Synthesis of Pyrrolidine Containing α-Hydroxyamide Core Structures as Inhibitors for HIV Proteases.

-A general and efficient approach to potentially useful inhibitors of HIV protease is developed. The polymer-supported catalyst PASC catalyzes the epoxidation of the starting olefins (conditions A) and promotes in the following step the opening of the epoxide ring with primary and secondary anilines.

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