ChemInform Abstract: Picolinic Acid as a Partner in the Mitsunobu Reaction: Subsequent Hydrolysis of Picolinate Esters under Essentially Neutral Conditions with Copper Acetate in Methanol.

Picolinic acid as a partner in the Mitsu

Picolinic acid as a partner in the Mitsunobu reaction: Subsequent hydrolysis of picolinate esters under essentially neutral conditions with copper acetate in methanol

✍ Tarek Sammakia; Jon S. Jacobs 📂 Article 📅 1999 🏛 Elsevier Science 🌐 French ⚖ 234 KB

The use of picolinic acid and 6-methyl picolinic acid in the Mitsunobu reaction has been studied. These substrates are excellent partners in the Mitsunobu reaction, and offer the added advantage that the resulting esters can be cleaved under essentially neutral conditions using Cu(OAc)2 and methanol