ChemInform Abstract: Photoreaction of Furocoumarins with DNA is Similarly Inhibited by Minor and Major Groove-Interacting Ligands.
✍ Scribed by M. GNIAZDOWSKI; Z. TOLWINSKA-STANCZYK; D. WILMANSKA; E. MALAGOCKA
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 33 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0931-7597
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✦ Synopsis
Photoreaction of Furocoumarins with DNA is Similarly Inhibited by Minor and Major Groove-Interacting Ligands.
-Methyl green (I), a major groove binding ligand and the minor groove binding ligands, netropsin (III) and proflavine derivative (II) inhibit similarly a monoadduct forming benzopsoralen as well as monoadduct and diadduct forming derivatives of psoralen. Caffeine (IV) shows an inhibitory effect on furocoumarin photobinding to DNA at 10 3 -fold higher concentration. It is concluded that both occupancy of the major and minor groove as well as intercalation hinder photobinding of furocoumarins to DNA.