ChemInform Abstract: Phosphine-Directed Stereo- and Regioselective Ni-Catalyzed Reactions of Grignard Reagents with Allylic Ethers.

✍ Scribed by M. T. DIDIUK; J. P. MORKEN; A. H. HOVEYDA

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 39 KB
• Volume: 29
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199823059

✦ Synopsis

Phosphine-Directed Stereo-and Regioselective Ni-Catalyzed Reactions of Grignard Reagents with Allylic Ethers.

-In the presence of a properly positioned internal Lewis base like a phosphine unit various acyclic and cyclic allylic ethers are regio-and stereoselectively methylated or phenylated. Under the nickel-catalyzed alkylation conditions alkene (Xb) undergoes an isomerization to the E isomer (XI). The various selectivity issues in the C-C bond forming process are discussed. -(DIDIUK, M. T.;