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ChemInform Abstract: Perhydropyrrolo(1,2-a)indole Synthesis: Diastereoselection in an Intramolecular Conjugate Addition of an Amine to a 1,4- Cyclohexadienone.

✍ Scribed by D. BLAND; D. J. HART; S. LACOUTIERE

Publisher: John Wiley and Sons
Year: 2010
Weight: 33 KB
Volume: 28
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199743133

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✦ Synopsis

Perhydropyrrolo(1,2-a)indole Synthesis: Diastereoselection in an Intramolecular Conjugate Addition of an Amine to a 1,4-Cyclohexadienone.

-The cyclization of the chiral aminocyclohexadienone (S)-(X) occurs with high diastereoselectivity affording the perhydroindole (XII). This reaction may be used in the control of the relative stereochemistry in the manzamine family of alkaloids. -(BLAND, D.; HART, D.

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