ChemInform Abstract: Pd-Catalyzed Asymmetric Allylic Alkylation of 3-Acetoxy-N-(tert-butyloxycarbonyl)-1,2,3,6-tetrahydropyridine — Preparation of Key Intermediates for Natural Product Synthesis.

Pd-Catalyzed Asymmetric Allylic Alkylati

Pd-Catalyzed Asymmetric Allylic Alkylation of 3-Acetoxy-N-(tert-butyloxycarbonyl)-1,2,3,6-tetrahydropyridine – Preparation of Key Intermediates for Natural Product Synthesis

✍ Simone Schleich; Günter Helmchen 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 322 KB

A convenient synthesis of racemic tetrahydropyridine 1 was up to 98%. Absolute configurations were determined for all compounds described. From the alkylation products (+)-and developed. Pd-catalyzed allylic alkylation of 1 with malonate and dimethylacetoxymalonate as nucleophiles with the (-)-2a, a