ChemInform Abstract: Parasite Glycoconjugates. Part 7. Synthesis of Further Substrate Analogues of Early Intermediates in the Biosynthetic Pathway of Glycosylphosphatidylinositol Membrane Anchors.

✍ Scribed by A. JUN. CROSSMAN; J. S. BRIMACOMBE; M. A. J. FERGUSON

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 35 KB
• Volume: 29
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199806251

✦ Synopsis

Parasite Glycoconjugates. Part 7. Synthesis of Further Substrate Analogues of Early Intermediates in the Biosynthetic Pathway of Glycosylphosphatidylinositol Membrane Anchors.

-Compounds (Ia)-(Ic) are prepared for biological evaluation with the α-(1 → 4)-Dmannosyltransferase of the protozoan parasite Trypanosoma brucei. Analogue (Ia) is a substrate for the protozoan but not for the corresponding mammalian enzyme whereas (Ib) and (Ic), in which the fatty-acid groups are replaced by alkyl groups, are acceptable substrates for both the protozoan and mammalian enzymes. Analogue (Id) is synthesized to define further the substrate specificities of the T. brucei enzymes. -(CROSSMAN, A. JUN.; BRIMACOMBE,