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ChemInform Abstract: Palladium(0) Catalyzed Nucleophilic Substitution on 2-Cyclopropylidene- phenoxyethanes.

โœ Scribed by A. M. BERNARD; P. P. PIRAS

Publisher
John Wiley and Sons
Year
2010
Weight
31 KB
Volume
28
Category
Article
ISSN
0931-7597

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โœฆ Synopsis

Palladium(0)

Catalyzed Nucleophilic Substitution on 2-Cyclopropylidene-phenoxyethanes.

-2-Cyclopropylidenephenoxyethanes (III), readily prepared by Wittig reaction of easily accessible ฮฑ-phenoxyethanones (I) with ylides (II), react with complete regioselectivity in Pd(0)-catalyzed nucleophilic substitutions with various soft carbon nucleophiles furnishing an easy entry to 5,6-methanoamino acids (cf. (VIII)). -

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ChemInform Abstract: The Stereochemical
ChemInform Abstract: The Stereochemical Dichotomy in Palladium(0)- and Nickel(0)-Catalyzed Allylic Substitution.
โœ C. N. FARTHING; P. KOCOVSKY ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 40 KB ๐Ÿ‘ 1 views

The Stereochemical Dichotomy in Palladium(0)-and Nickel(0)-Catalyzed Allylic Substitution. -In contrast to the known inversion-inversion steric pathway of allylic esters like (I), the corresponding acetate (IV), containing a phosphinous amide moiety, gives on treatment with malonate (II) in the pre