ChemInform Abstract: Palladium-Catalyzed Amination of Aryl Bromides: Use of Phosphinoether Ligands for the Efficient Coupling of Acyclic Secondary Amines.

✍ Scribed by J.-F. MARCOUX; S. WAGAW; S. L. BUCHWALD

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 32 KB
• Volume: 28
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199733098

✦ Synopsis

Palladium-Catalyzed Amination of Aryl Bromides: Use of Phosphinoether Ligands for the Efficient Coupling of Acyclic Secondary Amines.

-The substitution reaction of (I) with dibutylamine (IIa) is carried out with Pd2(dba)3 catalyst systems using different additional ligands in order to study the effect of their structure on the outcome of the coupling reaction. It is shown that Pd complexes derived from two ferrocenyl phosphines are highly effective for the aryl amination reaction with (II) and other acycylic sec. amines. These ligands represent the first examples in which (presumably) chelating ligands other than bis-phosphine have been employed for the title reaction. The use of this catalyst system is not effective with prim. amines including unhindered prim. anilines. -(MARCOUX,