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ChemInform Abstract: On the Relocation of the Amino Functionality to the Ethyl Side Chain in Aminoglutethimide: Synthesis and Aromatase-Inhibitory Activity of 3- (2′-N,N-Diethylamino)ethyl-3-phenylpiperidine-2,6-dione.

✍ Scribed by G. A. MONIZ; G. B. HAMMOND


Book ID
101857484
Publisher
John Wiley and Sons
Year
2010
Weight
30 KB
Volume
28
Category
Article
ISSN
0931-7597

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On the relocation of the amino functiona
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## Abstract Aminoglutethimide [3‐(4‐aminophenyl)‐3‐ethylpiperidine‐2,6‐dione] has been used clinically in the treatment of metastatic breast carcinoma. Inhibition of tumor growth is due to interference with estrogen biosynthesis. However, its action is not specific and its metabolism gives rise to

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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v