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ChemInform Abstract: Nucleosides and Nucleotides. Part 186. Synthesis and Biological Activities of Pyrimidine Carbocyclic Nucleosides with a Hydroxyamino Group Instead of a Hydroxymethyl Group at the 4′-Position of the Sugar Moiety.

✍ Scribed by Akira Ogawa; Satoshi Shuto; Motohiro Tanaka; Takuma Sasaki; Shuji Mori; Shiro Shigeta; Akira Matsuda

Publisher
John Wiley and Sons
Year
2010
Weight
35 KB
Volume
30
Category
Article
ISSN
0931-7597

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✦ Synopsis

Nucleosides and Nucleotides. Part 186. Synthesis and Biological Activities of Pyrimidine Carbocyclic Nucleosides with a Hydroxyamino Group Instead of a Hydroxymethyl Group at the 4'-Position of the Sugar Moiety. -The title compounds such as (IX) and (XIII) are prepared. The optical purity is introduced by a lipase-mediated enantioselective saponification of the meso diester (I). The most active compound in this series is (IX). The biological data are discussed. -(OGAWA, AKIRA; SHUTO,

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✍ Makoto Nomura; Kanji Endo; Satoshi Shuto; Akira Matsuda 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 35 KB 👁 1 views

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