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ChemInform Abstract: Nucleosides and Nucleotides. Part 156. Chelation-Controlled and Nonchelation-Controlled Diastereofacial Selective Thiophenol Addition Reactions at the 2′-Position of 2′-((Alkoxycarbonyl)methylene)-2′- deoxyuridines: Conversion of (Z)-2′-((Alkoxycarbonyl)methylene)-2′- deoxyuridines into Their (E)-Isomers.

✍ Scribed by A. E. A. HASSAN; S. SHUTO; A. MATSUDA

Publisher: John Wiley and Sons
Year: 2010
Weight: 33 KB
Volume: 28
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199718259

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✦ Synopsis

Nucleosides and Nucleotides. Part 156. Chelation-Controlled and Nonchelation-Controlled Diastereofacial Selective Thiophenol Addition Reactions at the 2'-Position of 2'-((Alkoxycarbonyl)methylene)-2'-deoxyuridines: Conversion of (Z)-2'-((Alkoxycarbonyl)methylene)-2'-deoxyuridines into Their (E)-Isomers.

-The Wittig reaction of (I) with (II) exclusively gives the (Z)-derivatives (III). This product can be converted to its E analogue (IX) following the sequence shown. -(HASSAN,

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ChemInform Abstract: Nucleosides and Nucleotides. Part 151. Conversion of (Z)-2′-( Cyanomethylene)-2′-deoxyuridines into Their (E)-Isomers via Addition of Thiophenol to the Cyanomethylene Moiety Followed by Oxidative syn- Elimination Reactions.

✍ A. E. A. HASSAN; N. NISHIZONO; N. MINAKAWA; S. SHUTO; A. MATSUDA 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 38 KB