ChemInform Abstract: Novel 4-Substituted Pyridine Derivatives: Practical Derivatization and Biological Profiles of Reversible H+/K+-ATPase Inhibitors.
β Scribed by K. NIIYAMA; T. NAGASE; T. FUKAMI; Y. TAKEZAWA; H. TAKEZAWA; Y. HIOKI; H. TAKESHITA; K. ISHIKAWA
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 37 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0931-7597
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Nicotinamide Derivatives as a New Class of Gastric H+/K+-ATPase Inhibitors. Part 1. Synthesis and Structure-Activity Relationships of N-Substituted 2-(Benzhydryl-and benzylsulfinyl)nicotinamides. -A series of title compounds, e.g. (IV), (VIII), (IX), and (X), is synthesized. Acid activation convert