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ChemInform Abstract: Novel 2-(2′-Furo[3,2-b]pyridinyl) Pyrrolidines: Potent Neuronal Nicotinic Acetylcholine Receptor Ligands.

✍ Scribed by R. L. ELLIOTT; K. B. RYTHER; D. J. ANDERSON; M. PIATTONI-KAPLAN; T. A. KUNTZWEILER; D. DONNELLY-ROBERTS; S. P. ARNERIC; M. W. HOLLADAY


Book ID
101859095
Publisher
John Wiley and Sons
Year
2010
Weight
30 KB
Volume
29
Category
Article
ISSN
0931-7597

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ChemInform Abstract: A Stereoselective S
✍ Simon J. F. Macdonald; Keith Mills; Julie E. Spooner; Richard J. Upton; Michael 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 32 KB 👁 2 views

A Stereoselective Synthesis via a 5-exo-trig Cyclization of trans-2-Oxohexahydro-2H-furo[3,2-b]pyrroles (Pyrrolidine-trans-lactones) -Potent, Novel Elastase Inhibitors. -With the title cyclization to (VI) as the key step, a stereoselective approach to a potent human neutrophile elastase inhibitor (