ChemInform Abstract: Non-Steroidal Antiinflammatory Agents. Part 22. Pyrrolidino-enaminones with an Acetic Acid Function at C-3: Synthesis and Inhibition of the Enzymes Cyclooxygenase and 5-Lipoxygenase.

✍ Scribed by G. DANNHARDT; A. BAUER; U. NOWE

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 30 KB
• Volume: 28
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199718145

✦ Synopsis

Non-Steroidal Antiinflammatory Agents.

Part 22. Pyrrolidinoenaminones with an Acetic Acid Function at C-3: Synthesis and Inhibition of the Enzymes Cyclooxygenase and 5-Lipoxygenase.

-Two representative samples of the title pyrrolidino-enaminones (VI) are synthesized starting from thiolactam (I) and evaluated for their potencies to inhibit cyclooxygenase and 5-lipoxygenase. Both the enaminones display only weak inhibitory activity towards the enzymes. -(DANNHARDT, G.; BAUER, A.;