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ChemInform Abstract: NMR Structure of Phospho-Tyrosine Signaling Complexes

โœ Scribed by Carol Beth Post; Beverly S. Gaul; Elan Zobar Eisenmesser; Michael I. Schneider

Publisher
John Wiley and Sons
Year
2010
Weight
25 KB
Volume
30
Category
Article
ISSN
0931-7597

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A structural basis for activation and substrate specificity of src tyrosine kinases, and regulation of protein-protein association by tyrosine phosphorylation is described. Lyn, a src-family tyrosine kinase, recognizes and phosphorylates the immunoreceptor tyrosine-based activation motif, ITAM, a cr