ChemInform Abstract: Nitroquinolones with Broad-Spectrum Antimycobacterial Activity in vitro.

✍ Scribed by Marino Artico; Antonello Mai; Gianluca Sbardella; Silvio Massa; Chiara Musiu; Stefania Lostia; Francesca Demontis; Paolo La Colla

• Book ID: 101889065
• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 33 KB
• Volume: 30
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199937151

✦ Synopsis

Nitroquinolones with Broad-Spectrum Antimycobacterial Activity in vitro.

-A variety of quinolonecarboxylic acids containing fluoro-, nitro-or amino-substituents at the 6-position [cf. (VIII), (XIV)] are synthesized and evaluated for their antibacterial activities. Derivative (VIIb), the most active compound of this series, proves to be more potent and selective against Gram-positive bacteria and mycobacteria than the reference drugs ofloxacin and ciprofloxacin.