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ChemInform Abstract: New β-Carboline Derivatives by Double-Cyclization of Chiral α-Heteroarylmethylamino Esters.

✍ Scribed by Heike Faltz; Juergen Liebscher


Publisher
John Wiley and Sons
Year
2010
Weight
31 KB
Volume
30
Category
Article
ISSN
0931-7597

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✦ Synopsis


New β-Carboline Derivatives by Double-Cyclization of Chiral α-Heteroarylmethylamino Esters. -Dialkylation of the amino acid esters (II) with o-bromo-bromomethylhetarenes (I) gives the N,N-disubstituted esters. A following BuLi mediated double cyclization via bromo-lithium exchange yields the azabicyclo[3.3.1]nonanes (IV). -(FALTZ, HEIKE; LIEBSCHER,


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