ChemInform Abstract: New Potent Antihyperglycemic Agents in db/db Mice: Synthesis and Structure-Activity Relationship Studies of (4-Substituted benzyl)( trifluoromethyl)pyrazoles and -pyrazolones.
✍ Scribed by K. L. KEES; J. J. JUN. FITZGERALD; K. E. STEINER; J. F. MATTES; B. MIHAN; T. TOSI; D. MONDORO; M. L. MCCALEB
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 31 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0931-7597
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✦ Synopsis
New Potent Antihyperglycemic Agents in db/db Mice: Synthesis and Structure-Activity Relationship Studies of (4-Substituted benzyl)( trifluoromethyl)pyrazoles and -pyrazolones. -A benzyl group at C-4, substituted by methylthio, methylsulfinyl, or ethyl in para-position, in combination with trifluoromethyl at C-5 of pyrazol-3-ones; such as the tautomeric lead compound (Ia) and its analogues (Ib)-(Ie) and (II), generates potent antihyperglycemic agents in obese, diabetic db/db mice with 16-30% reduction in plasma glucose at 2 mg/kg dose. -(KEES, K. L.; FITZGERALD,