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ChemInform Abstract: New NO-Donors with Antithrombotic and Vasodilating Activities. Part 16. 3-Amino-1,2,4-oxadiazol-5-ones as Prodrugs for Hydroxyguanidines.

โœ Scribed by K. REHSE; S. BADE


Publisher
John Wiley and Sons
Year
2010
Weight
31 KB
Volume
28
Category
Article
ISSN
0931-7597

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New NO-Donors with Antithrombotic and Va
โœ Klaus Rehse; Stephan Bade ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 636 KB

Nineteen 4-substituted 1,2,4-oxadiazol-5-ones (6a-s) were prepared as prodrugs for lipophilic hydroxyguanidines which should be metabolized in vivo to nitric oxide. This hypothesis was tested indirectly by measuring the antithrombotic properties of these compounds 2 h after oral administration to ra