New NO-Donors with Antithrombotic and Va
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Klaus Rehse; Stephan Bade
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Article
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1996
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John Wiley and Sons
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English
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Nineteen 4-substituted 1,2,4-oxadiazol-5-ones (6a-s) were prepared as prodrugs for lipophilic hydroxyguanidines which should be metabolized in vivo to nitric oxide. This hypothesis was tested indirectly by measuring the antithrombotic properties of these compounds 2 h after oral administration to ra