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ChemInform Abstract: New Brominated and Halogen-Less Derivatives and Structure—Activity Relationship of Azaphilones Inhibiting gp120-CD4 Binding.

✍ Scribed by Keiichi Matsuzaki; Harumi Tahara; Junji Inokoshi; Haruo Tanaka; Rokuro Masuma; Satoshi Omura

Publisher
John Wiley and Sons
Year
2010
Weight
29 KB
Volume
30
Category
Article
ISSN
0931-7597

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✦ Synopsis

New Brominated and Halogen-Less Derivatives and Structure-Activity Relationship of Azaphilones Inhibiting gp120-CD4 Binding.

-New ochrephilone (III) and isochromophilone (Ib) are isolated from Penicillium multicolor FO-2338, fermented in a medium containing KBr, and characterized together with three known compounds (Ia), (II) and (IV). These derivatives and various other azaphilones are examined by gp120-CD4 binding assay. Compound (III) is found to be the strongest inhibitor.

-(MAT-

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