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ChemInform Abstract: N4-(ω-Aminoalkyl)-1- [(ω-aminoalkyl)amino]-4-acridinecarboxamides: Novel, Potent, Cytotoxic, and DNA-Binding Agents.

✍ Scribed by Ippolito Antonini; Paolo Polucci; Lloyd R. Kelland; Silvano Spinelli; Nicoletta Pescalli; Sante Martelli


Publisher
John Wiley and Sons
Year
2001
Weight
30 KB
Volume
32
Category
Article
ISSN
0931-7597

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1-[(ω-Aminoalkyl)amino]-4-[N-(ω-aminoalkyl)carbamoyl]-9-oxo-9,10dihydroacridines as Intercalating Cytotoxic Agents: Synthesis, DNA Binding, and Biological Evaluation. -DNA-binding results from thermal denaturation and fluorescence-based studies are reported for the title compounds such as (III), ob