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ChemInform Abstract: N-ω-Carbethoxypentyl-4-quinolones: A New Class of Leukotriene Biosynthesis Inhibitors.

✍ Scribed by N. DESIDERI; I. SESTILI; M. L. STEIN; S. MANARINI; G. DELL'ELBA; C. CERLETTI

Publisher
John Wiley and Sons
Year
2010
Weight
34 KB
Volume
28
Category
Article
ISSN
0931-7597

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✦ Synopsis

N-ω-Carbethoxypentyl-4-quinolones: A New Class of Leukotriene Biosynthesis Inhibitors.

-Alkylation of (I) provides a mixture of Oand N-alkylated products with prevalence of the first ones in most cases. While oxyhexanoate derivatives (III) as well as oxyhexanoic acid derivatives (V) are not biologically active with regard to the inhibition of LTB4 and thromboxane B2 production, the N-alkylated compounds (IV) and (VI) prove to inhibit LTB4 biosynthesis, but their activity is modest in comparison to other known inhibitors.

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