N-Heterocyclic Carbene-Mediated Enantios
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Carmen Concellรณn; Nicolas Duguet; Andrewโ
D. Smith
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Article
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2009
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John Wiley and Sons
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English
โ 282 KB
## Abstract Chiral Nโheterocyclic carbenes (NHCs) mediate the enantioselective addition of 2โphenylphenol to unsymmetrical alkylarylketenes, delivering ฮฑโalkylโฮฑโarylacetic acid derivatives with good levels of enantiocontrol (up to 84% __ee__). Enantiodivergent stereochemical outcomes are observed