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ChemInform Abstract: N-Heterocyclic Carbene Mediated Enantioselective Addition of Phenols to Unsymmetrical Alkylarylketenes.

โœ Scribed by Carmen Concellon; Nicolas Duguet; Andrew D. Smith


Book ID
102050434
Publisher
John Wiley and Sons
Year
2010
Weight
33 KB
Volume
41
Category
Article
ISSN
0931-7597

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N-Heterocyclic Carbene-Mediated Enantios
โœ Carmen Concellรณn; Nicolas Duguet; Andrewโ€…D. Smith ๐Ÿ“‚ Article ๐Ÿ“… 2009 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 282 KB

## Abstract Chiral Nโ€heterocyclic carbenes (NHCs) mediate the enantioselective addition of 2โ€phenylphenol to unsymmetrical alkylarylketenes, delivering ฮฑโ€alkylโ€ฮฑโ€arylacetic acid derivatives with good levels of enantiocontrol (up to 84% __ee__). Enantiodivergent stereochemical outcomes are observed